Opening statements were given in the trial for an Aurora dentist accused of killing his wife Tuesday morning in Arapahoe County. Prosecutors say James Craig, 47, poisoned his wife's protein shakes because of financial troubles and an affair with another woman.

"This is Angela Craig on one of the last days of her life," said prosecutor Ryan Brackley, showing a photo of the 43-year-old mother in a hospital bed.

Using a handful of photos of Angela in the hospital, the prosecution opened their case against the man they believe killed his wife of 23 years. Brackley said the mother of six was poisoned multiple times, including while she was in the hospital in March 2023.

"He went into that room to murder her, to deliberately and intentionally end her life with a fatal dose of cyanide," Brackley said of James Craig.

Citing money issues and infidelity as a motive, Brackley said the dentist poisoned his wife using a mix of arsenic, cyanide, and tetrahydrozoline -- a medicine commonly found in eyedrops, like the Visine that James Craig allegedly purchased in bulk. Among the evidence the jury will see in the weeks-long trial, said the prosecution, is James Craig's online research for those items and ways to hide a murder.

"Those internet searches -- 'How to make a murder look like a heart attack,'" he said.

However, the defense argues investigators used "tunnel vision" when they arrested James Craig, and said the case is based on "speculation and assumption." Defense attorney Ashley Witham told the jury they do not dispute that James Craig was having an affair, but argued that that's not a motive because he'd had numerous affairs throughout the marriage.

"You may not like him, you may not think he's a good husband," Witham said in her opening statement, "but that's not what you're here to decide."

James Craig's attorney described the case as "about a lot of things that are broken." That includes the investigation, the defendant, and Angela. Witham told the jury Angela was a struggling mother, and her death may have been a suicide, saying the case is not as "cut and dry" as the prosecution claims.

"This case, from the very beginning, started with blinders," she said. "So, as the defense, we're going to ask you to remove the blinders from this case and to look at everything."

James Craig remains in custody. He is charged with murder, plus solicitation to commit murder for allegedly seeking a jail inmate to kill an investigator and solicitation to commit perjury for allegedly trying to get people to lie for him -- including a daughter whom he messaged asking if she would get a computer and destroy it. Prosecutors showed a message they said was from James Craig to his daughter.

"And I love you Belle, I'm sorry to ever have asked for this help."